Antigen-binding proteins comprising a linker which confers restricted conformational flexibility

Protéines se liant aux antigènes comprenant un liant conférant une flexibilité conformationnelle limitée

Antigenbindungsproteine mit einer Kopplung, die die strukturelle Beweglichkeit einschränkt

  • Inventors:
  • Assignees: Unilever Plc
  • Publication Date: May 24, 2000
  • Publication Number: EP-1002861-A1

Abstract

Use of a polypeptide linker group, the amino acid sequence of which group confers restricted conformational flexibility, as a linking group to link binding units, preferably antigen binding units comprising heavy chain variable domains derived from an immunoglobulin naturally devoid of light chains, in a multivalent binding protein.

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